Key publications

I have published more than 100 refereed articles (total impact factor: 663), which have attracted over 4600 citations. These include 3 publications in Cell, one in Aging Cell, 8 in the Proceedings of the National Academy of Sciences USA, 5 in Journal of Biological Chemistry, 3 in EMBO Journal, and one in Science. I have also published many highly cited review articles in leading journals such as Trends in Molecular Medicine, Brain Research Reviews, Molecular Psychiatry, Nature Reviews Neuroscience (2), and Progress in Neurobiology (3).

  1. 1.     * Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wölfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Götz J (2010) Dendritic function of tau mediates amyloid-β toxicity in Alzheimer’s disease mouse models, Cell 142: 387–97 (54 citations, ARC DP0773577, DP1096491)

 

A paradigm shift linking the two hallmarks of Alzheimer’s disease, amyloid-β and tau, in the dendrite; full rescue of Alzheimer’s disease-associated phenotype was achieved in amyloid-β-forming mice, both genetically and pharmacologically.

 

  1. * Ittner LM, Fath T, Ke Y, Bi M, van Eersel J, Li KM, Gunning P and Götz J (2008)Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia, Proc Natl Acad Sci USA 105: 15997–16002 (37 citations, ARC DP0773577)

 

A model of Dopa-responsive early-onset Parkinsonism, identifying impaired axonal transport as a central patho-mechanism. Tau traps the kinesin adapter protein JIP1 in the soma, suggesting JIP1 as a drug target.

 

  1. * Götz J, Ittner LM (2008) Animal models of Alzheimer’s disease and frontotemporal dementia, Nature Rev. Neurosci. 9: 532–44 [Featured article, July] (128 citations, ARC DP0773577)

 

One of my major reviews of transgenic models of neurodegeneration, and the basis for my plenary lecture (more than 1,000 participants) at the prestigious ICAD08 (International Conference on Alzheimer’s Disease) meeting.

 

  1. Chen F, Wollmer A, Hoerndli F, Münch G, Kuhla B, Rogaev EI, Tsolaki M, Papassotiropoulos A, Götz J (2004) Role for glyoxalase I in Alzheimer’s disease, Proc Natl Acad Sci USA 101: 7687–92 (88 citations)

 

Demonstrating the potential of transcriptomics applied to models of neurodegeneration, and identifying a role for glyoxalase I in detoxifying methylglyoxal (a metabolite linked to mutagenesis, ageing and diabetes) in neurons.

 

  1. * Kins S, Crameri A, Evans DRH, Hemmings BA, Nitsch RM, Götz J (2001) Reduced PP2A activity induces abnormal phosphorylation and compartmentalization of tau in transgenic mice, J. Biol. Chem. 276: 38193–38200 (103 citations)

 

Novel approach of dominant negative mutant expression of the protein phosphatase 2A’s (PP2A’s) catalytic subunit – the complete knockout is lethal –identified its neuronal substrates and the specific regulatory subunits involved.

 

  1. * Götz J, Chen F, van Dorpe J, Nitsch RM (2001) Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Abeta42 fibrils, Science 293: 1491–95 (566 citations)

Long-sought evidence for the amyloid cascade hypothesis that links amyloid-β and tau (the two hallmark lesions) in Alzheimer’s disease, highlighted by an accompanying ‘Perspectives’ article in Science.

 

  1. 7.     Shmerling D, Hegyi I, Fischer M, Blättler T, Brandner T, Götz J, Rülicke T, Flechsig E, Cozzio A, Mering C, Hangartner C, et.al. (1998) Expression of amino-terminally trun­cated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell 93: 203–14 (303 citations)

 

Prions are infectious agents of transmissible diseases including mad cow disease. Using a combinatorial transgenic approach we identified functional domains of the Prion protein that are necessary for its infectivity.

 

  1. Götz J, Probst A, Ehler E, Hemmings B, Kues W (1998) Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα. Proc Natl Acad Sci USA 95: 12370–75 (110 citations)

 

The first gene targeting study of the heterotrimeric enzyme PP2A showing its essential role in forming the mesoderm, one of the three primary germ layers in the early embryo.

 

  1. 9.     * Götz J, Probst A, Spillantini MG, Schäfer T, Jakes R, Bürki K, Goedert M (1995) Somato-dendritic localisation and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J. 14: 1304–13 (204 citations)

 

The first tau transgenic mouse model; we revealed that the mice had a pre-tangle phenotype, a critical foundation for the development of human treatment strategies targeting tau.

 

  1. 10.       Hebert JM, Rosenquist T, Götz J, Martin GR (1994) FGF5 as a regulator of the hair growth:

Evidence from targeted and spontaneous mutations. Cell 78: 1017–25 (303 citations)

 

The basis for identifying and validating the growth factor Fibroblast Growth Factor 5 (Fgf5) as a crucial gene in hair length, with possible pharmaceutical implications for the treatment of alopecia.

 

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