Established techniques in the laboratory include, in addition to standard techniques in molecular and cellular biology:
- Generation and phenotypic analysis of transgenic mice including
- Behavioural analysis of mice (memory and motor tests)
- Primary neuronal cultures, general cell culture
- Histology, immunohistochemistry, silver impregnation techniques
- C. elegans techniques including the ballistic bombardment to establish transgenic lines
- Transcriptomics mRNAs/miRNAs (SAGE, Affymetrix gene chips)
- Proteomics (HPLC methods plus iTRAQ quantitative proteomics)
- Molecular and biochemical techniques, enzymatic assays, ELISAs
- Active and passive immunisation, generation of monoclonal antibodies
